Publications

1. Papers
2. Reviews
3. Case Reports
3. Letters


  Papers

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  Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses

J P Sturgeon, C D Bourke, A J Prendergast
image The Pediatric Infectious Disease Journal 2019  

This paper explores the immune changes seen in children admitted to hospital with non-critical infections. The same monocyte HLA-DR reductions are seen as in more critically ill children, such changes being associated with future functional immunosuppression. These chages were also associated with increased gut permeability, and circulating endotoxin, suggesting a cause for the changes.
 
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C-Reactive Protein (CRP) levels in neonatal meningitis in England: an analysis of national variations in CRP cut-offs for lumbar puncture

J P Sturgeon, B Zanetti, D Lindo
image BMC Pediatrics 2018
This paper looks at the CRP levels that NHS trusts in England considering doing lumbar punctures in neonates with suspected sepsis, and how they differ from the NICE guidance. Many trusts do not follow the NICE guidance of CRP >10mg/mL for lumbar punctures, and this is reflected in the poor sensitivity and specificity seen in neonates with meningitis from across the country.
 
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Platelet-leucocyte aggregation is augmented in cirrhosis andfurther increased by platelet transfusion

S Stoy, V C Patel, J P Sturgeon, G K Manakkat Vijay, T Lisman, W Bernal, D L Shawcross
image Alimentary Pharmacology and Therapeutics 2018  
Building on my previous work below, this paper looks at the effect platelets (or their secreted components) have on leukocyte function, and that in patients with cirrhosis the transfusion of platelets affects other leukocyte functions in vitro. Given the balanced immune dysfunction in cirrhosis, this suggests there needs to be more consideration of the true effects of transfusing these patients.
 
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  Could Abnormal Neutrophil-Platelet Interactions and Complex Formation Contribute to OxidativeStress and Organ Failure in Cirrhosis?

J P Sturgeon, G K Manakkat Vijay, J Ryan, W Bernal, D L Shawcross
image Hepatology 2015  
This short report looks at the effect that platelets from patients with cirrhosis have on neutrophils, and shows they are less good at inhiiting oxidative burst than healthy control platelets. This could suggest that there might be some effect from any transfusion of healthy platelets in such patients.
 
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The Variable Rate Intravenous Insulin Infusion Protocol

B Collard, J P Sturgeon, N Patel, S Asharia
image BMJ Open Quality 2013   
This paper looks at the service improvement of a trialled new insulin infusion protocol in partients needing a sliding scale.
 

  Reviews

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Postdischarge interventions for children hospitalized with severe acute malnutrition: a systematic review and meta-analysis

CCA Noble, JP Sturgeon, M Bwakura-Dangarembizi, MP Kelly, B Amadi, AJ Prendergast
image American Journal of Clinical Nutrition 2021
A systematic review paper examining independent risk factors for interventions for post-discharge mortality in children hospitalised with severe acute malnutrition. Several biological and psychosocial interventions including pre/pro biotics, and psychological interventions show promise in improving outcomes in children following hospitalization for SAM, and should be further explored with larger, powered, randomized controlled trials.
 
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Predictors of inpatient mortality among children hospitalized for severe acute malnutrition: a systematic review and meta-analysis

R Karunaratne*, J P Sturgeon*, R Patel, A J Prendergast
image American Journal of Clinical Nutrition 2020
A review paper examining independent risk factors for in-patient mortality in severe acute malnutrition (SAM). Examining studies published since 2000, we have shown that there are seven independent predictors for in-patient mortality in children under 60 months admitted with SAM: HIV, Weight-for-height z-score, diarrhoea, pneumonia, presence of shock, and lack of appetite.
This article has an accompanying editorial.
 
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Recent insights into thepathogenesis of hepaticencephalopathy and treatments

J P Sturgeon, D L Shawcross
image Expert Reviews in Gastroenterology and Hepatology 2015
A review paper examining the relationship between inflammation, ammonia, and hepatic encephalopathy, as well as new treatments for the disease incliding non-absorbable antiiotics such as rifaximin-a.
 

  Case Reports

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Going Out on a Limb: Do Not Delay Diagnosis of Necrotizing Fasciitis in Varicella Infection

J P Sturgeon, L Segal, A Verma
image Pediatric Emergency Care 2015  

 

  Letters

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Antibiotic prescribing in the paediatric emergency department and the impact of education

D Gkentzi, R Ramachandran, E Day, L Anguvaa, M Borg, N Siva, J Sturgeon, T Jaiganesh, M Sharland, K Doerholt
image Journal of paediatrics and child health 2014
 
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Intravenous Access in Children in the Emergency Department

J P Sturgeon, R Lifford, F Cantle
image Pediatric emergency care 2014