Platelet-leucocyte aggregation is augmented in cirrhosis andfurther increased by platelet transfusion
S Stoy, V C Patel, J P Sturgeon, G K Manakkat Vijay, T Lisman, W Bernal, D L Shawcross
Alimentary Pharmacology and Therapeutics 2018
Building on my previous work below, this paper looks at the effect platelets (or their secreted components) have on leukocyte function, and that in patients with cirrhosis the transfusion of platelets affects other leukocyte functions in vitro
. Given the balanced immune dysfunction in cirrhosis, this suggests there needs to be more consideration of the true effects of transfusing these patients.